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KMID : 1149220140220010105
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Korean Journal of Oriental Medical Prescription
2014 Volume.22 No. 1 p.105 ~ p.112
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Methanol extract from radix of Glycyrrhizae uralensis attenuate methamphetamine-induced hyperlocomotor activity
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Zhao Zheng-Lin
Wang Yan
Lin Feng
Fu Hui
Zhou Fu-Bo
Chang Su-Chan
Han Nu-Ri
Jung Dae-Hwa
Yang Chae-Ha
Kim Sang-Chan
Zhao Rong-Jie
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Abstract
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Background and objective: Methamphetamine (Meth) is a widely abused psychostimulant that produces hyperlocomotion in rodents. Radix of Glycyrrhizae uralensis comprises a variety of bioactive components that have neuroprotective effects. In a previous study, we have demonstrated methanol extracts from radix of Glycyrrhizae uralensis (MEGR) suppress acute cocaine-induced extracellular dopamine release in the nucleus accumbens. In the present study, we investigated the effect of MEGR on acute Meth-induced hyperlocomotion.
Methods: Male Sprague?Dawley rats were orally administered with MEGR (60 mg/kg and 180 mg/kg) 60 min prior to an intraperitoneal injection of Meth (1.0 mg/kg).
Results: Behavioral analysis showed acute Meth greatly increased locomotor activities, while pretreatment with MEGR dose dependently inhibited the hyperlocomotion. In parallel, there were markedly increased levels of dopamine and its metabolite 3, 4-dihydroxyphenylacetic acid in the nucleus accumbens tissues in Meth-treated rats, which were also almost completely reversed by 180 mg/kg MEGR.
Conclusions: These results showed that radix of Glycyrrhizae uralensis attenuates Meth-induced hyperlocomotion by inhibiting dopamine synthesis and utilization, suggesting that radix of Glycyrrhizae uralensis might be effective in blocking the rewarding effect of Meth.
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KEYWORD
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Methamphetamine, Glycyrrhizae uralensis, Locomotion, Dopamine, Nucleus accumbens
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